Phosphoproteomics data classify hematological cancer cell lines according to tumor type and sensitivity to kinase inhibitors

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Disorder-induced double resonant Raman process in graphene

An analytical study is presented of the double resonant Raman scattering process in graphene, responsible for the D and D$^{\prime}$ features in the Raman spectra. This work yields analytical expressions for the D and D$^{\prime}$ integrated Raman intensities that explicitly show the dependencies on laser energy, defect concentration, and electronic lifetime. Good agreement is obtained between the analytical results and experimental measurements on samples with increasing defect concentrations and at various laser excitation energies. The use of Raman spectroscopy to identify the nature of defects is discussed. Comparison between the models for the edge-induced and the disorder-induced D band intensity suggests that edges or grain boundaries can be distinguished from disorder by the different dependence of their Raman intensity on laser excitation energy. Similarly, the type of disorder can potentially be identified not only by the intensity ratio $I_{\mathrm{D}}/I_{\mathrm{D}^{\prime}}$, but also by its laser energy dependence. Also discussed is a quantitative analysis of quantum interference effects of the graphene wavefunctions, which determine the most important phonon wavevectors and scattering processes responsible for the D and D$^{\prime}$ bands.Comment: 10 pages, 4 figure

Moving embedded lattice solitons

It was recently proved that isolated unstable "embedded lattice solitons" (ELS) may exist in discrete systems. The discovery of these ELS gives rise to relevant questions such as the following: are there continuous families of ELS?, can ELS be stable?, is it possible for ELS to move along the lattice?, how do ELS interact?. The present work addresses these questions by showing that a novel differential-difference equation (a discrete version of a complex mKdV equation) has a two-parameter continuous family of exact ELS. The numerical tests reveal that these solitons are stable and robust enough to withstand collisions. The model may apply to the description of a Bose-Einstein condensate with dipole-dipole interactions between the atoms, trapped in a deep optical-lattice potential.Comment: 13 pages, 11 figure

Selective and highly efficient dye scavenging by a pH-responsive molecular hydrogelator

A structurally simple low molecular weight hydrogelator derived from isophthalic acid forms robust pH-responsive hydrogels capable of highly efficient and selective dye adsorption

Collective pinning of imperfect vortex lattices by material line defects in extreme type-II superconductors

The critical current density shown by a superconductor at the extreme type-II limit is predicted to follow an inverse square-root power law with external magnetic field if the vortex lattice is weakly pinned by material line defects. It acquires an additional inverse dependence with thickness along the line direction once pinning of the interstitial vortex lines by material point defects is included. Moderate quantitative agreement with the critical current density shown by second-generation wires of high-temperature superconductors in kG magnetic fields is achieved at liquid-nitrogen temperature.Comment: 10 pages, 3 figures, 2 tables. To appear in Physical Review

Condensation in an Economic Model with Brand Competition

We present a linear agent based model on brand competition. Each agent belongs to one of the two brands and interacts with its nearest neighbors. In the process the agent can decide to change to the other brand if the move is beneficial. The numerical simulations show that the systems always condenses into a state when all agents belong to a single brand. We study the condensation times for different parameters of the model and the influence of different mechanisms to avoid condensation, like anti monopoly rules and brand fidelity.Comment: Accepted in: International Journal of Modern Physics

CARMA observations of massive Planck-discovered cluster candidates at z>0.5 associated with WISE overdensities: Breaking the size-flux degeneracy

We use a Bayesian software package to analyze CARMA-8 data towards 19 unconfirmed Planck SZ-cluster candidates from Rodriguez-Gonzalvez et al. (2015), that are associated with significant overdensities in WISE. We used two cluster parameterizations, one based on a (fixed shape) generalized-NFW pressure profile and another based on a beta-gas-density profile (with varying shape parameters) to obtain parameter estimates for the nine CARMA-8 SZ-detected clusters. We find our sample is comprised of massive, Y_{500}=0.0010 \pm 0.0015 arcmin^2, relatively compact, theta_{500}= 3.9 \pm 2.0 arcmin systems. Results from the beta model show that our cluster candidates exhibit a heterogeneous set of brightness-temperature profiles. Comparison of Planck and CARMA-8 measurements showed good agreement in Y_{500} and an absence of obvious biases. We estimated the total cluster mass M_{500} as a function of z for one of the systems; at the preferred photometric redshift of 0.5, the derived mass, M_{500} \approx 0.8 \pm 0.2 \times 10^{15} Msun. Spectroscopic Keck/MOSFIRE data confirmed a galaxy member of one of our cluster candidates to be at z=0.565. Applying a Planck prior in Y_{500} to the CARMA-8 results reduces uncertainties for both parameters by a factor >4, relative to the independent Planck or CARMA-8 measurements. We here demonstrate a powerful technique to find massive clusters at intermediate z \gtrsim 0.5 redshifts using a cross-correlation between Planck and WISE data, with high-resolution follow-up with CARMA-8. We also use the combined capabilities of Planck and CARMA-8 to obtain a dramatic reduction by a factor of several, in parameter uncertainties.Comment: 26 pages, 8 figures, appearing in MNRAS (responded to referee report

The RNA-binding protein, ZFP36L2, influences ovulation and oocyte maturation

ZFP36L2 protein destabilizes AU-rich element-containing transcripts and has been implicated in female fertility. In the C57BL/6NTac mouse, a mutation in Zfp36l2 that results in the decreased expression of a form of ZFP36L2 in which the 29 N-terminal amino acid residues have been deleted, ΔN-ZFP36L2, leads to fertilized eggs that arrest at the two-cell stage. Interestingly, homozygous ΔN-Zfp36l2 females in the C57BL/6NTac strain release 40% fewer eggs than the WT littermates (Ramos et al., 2004), suggesting an additional defect in ovulation and/or oocyte maturation. Curiously, the same ΔN-Zfp36l2 mutation into the SV129 strain resulted in anovulation, prompting us to investigate a potential problem in ovulation and oocyte maturation. Remarkably, only 20% of ΔN-Zfp36l2 oocytes in the 129S6/SvEvTac strain matured ex vivo, suggesting a defect on the oocyte meiotic maturation process. Treatment of ΔN-Zfp36l2 oocytes with a PKA inhibitor partially rescued the meiotic arrested oocytes. Furthermore, cAMP levels were increased in ΔN-Zfp36l2 oocytes, linking the cAMP/PKA pathway and ΔN-Zfp36l2 with meiotic arrest. Since ovulation and oocyte maturation are both triggered by LHR signaling, the downstream pathway was investigated. Adenylyl cyclase activity was increased in ΔN-Zfp36l2 ovaries only upon LH stimulation. Moreover, we discovered that ZFP36L2 interacts with the 3′UTR of LHR mRNA and that decreased expression levels of Zfp36l2 correlates with higher levels of LHR mRNA in synchronized ovaries. Furthermore, overexpression of ZFP36L2 decreases the endogenous expression of LHR mRNA in a cell line. Therefore, we propose that lack of the physiological down regulation of LHR mRNA levels by ZFP36L2 in the ovaries is associated with anovulation and oocyte meiotic arrest.Fil: Ball, Christopher B.. University of North Carolina; Estados UnidosFil: Rodriguez, Karina F.. National Institutes of Health; Estados UnidosFil: Stumpo, Deborah J.. National Institutes of Health; Estados UnidosFil: Ribeiro Neto, Fernando. National Institutes of Health; Estados UnidosFil: Korach, Kenneth S.. National Institutes of Health; Estados UnidosFil: Blackshear, Perry J.. University of Duke; Estados Unidos. National Institutes of Health; Estados UnidosFil: Birnbaumer, Lutz. National Institutes of Health; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ramos, Silvia B. V.. University of North Carolina; Estados Unido

Wigner Crystal State for the Edge Electrons in the Quantum Hall Effect at Filling ν=2\nu = 2

The electronic excitations at the edges of a Hall bar not much wider than a few magnetic lengths are studied theoretically at filling $\nu = 2$. Both mean-field theory and Luttinger liquid theory techniques are employed for the case of a null Zeeman energy splitting. The first calculation yields a stable spin-density wave state along the bar, while the second one predicts dominant Wigner-crystal correlations along the edges of the bar. We propose an antiferromagnetic Wigner-crystal groundstate for the edge electrons that reconciles the two results. A net Zeeman splitting is found to produce canting of the antiferromagnetic order.Comment: 22 pgs. of PLAIN TeX, 1 fig. in postscript, published versio